Prisco's Week 6 NFL Picks: Seahawks Favored on TNF, Bucs Upset Steelers

What Happened

CBS Sports' resident picks guru Pete Prisco dropped his Week 6 NFL predictions, and there's a couple of calls worth paying attention to before you lock in your bets or fantasy lineups. The headline pick: Seahawks over Broncos on Thursday Night Football, a game that kicks off the week and sets the tone for everything else. Prisco is also calling for an upset in Pittsburgh, with the Buccaneers knocking off the Steelers in what most books have as a toss-up or slight Pittsburgh lean.

Why Prisco Likes Seattle

Thursday night games are always tricky — short rest, limited practice time, and a national audience watching every mistake. Prisco's lean toward Seattle suggests he sees an edge in matchup or momentum that the betting public might be sleeping on. Denver has had flashes of strong defense this season, but road trips on a short week have historically favored the home team, and Prisco's track record on primetime games makes this one worth a second look if you're building a parlay or setting your survivor pool pick.

The Buccaneers-Steelers Upset Call

The more eyebrow-raising pick here is Tampa Bay over Pittsburgh. The Steelers have built a reputation under their current regime for grinding out wins even when they're not the flashiest team on paper, which makes any upset call against them notable. Prisco's confidence in the Bucs suggests he's banking on Tampa Bay's offensive firepower or a defensive mismatch that could swing field position and turnovers in their favor. For fantasy managers and bettors alike, this is the kind of pick that either validates a contrarian bet or serves as a reminder why Vegas lines exist in the first place.

How to Use These Picks

Prisco's weekly picks are more than just win-loss predictions — they're a snapshot of how a veteran NFL watcher reads matchups, coaching tendencies, and situational football. Whether you're filling out a confidence pool, building a same-game parlay, or just want an informed gut check before kickoff, cross-referencing expert picks like these with your own research can sharpen your decision-making. Just remember: even the best handicappers miss plenty of games, so treat these as one data point among many, not gospel.

What Reader Should Know

If you're watching Thursday Night Football, keep an eye on how Seattle handles the short week and whether Denver's defense can generate enough pressure to flip the script. And come Sunday, the Buccaneers-Steelers game could end up being one of the more talked-about results of the week if Prisco's upset call hits. Either way, Week 6 is shaping up to have some real drama baked in beyond just the point spreads.